ea0065p133 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019
White Gemma
, Masucci Michael
, Anandappa Samantha
, Joshi Mamta
, McGowan Barbara
, Obholzer Rupert
, Jacques Audrey
, Christodoulou Dimitra
, Izatt Louise
, Velusamy Anand
, Carroll Paul
Background: Pathogenic variants in genes encoding Succinate Dehydrogenase subunits B and D (SDHB/SDHD) predispose to Phaeochromocytoma and Paraganglioma (PPGL). Cascade genetic screening identifies relatives at risk and allows surveillance screening to enable early detection of PPGLs.Methods: Retrospective analysis of genetic databases and hospital records between January 2000 and December 2018 identified relatives carrying SDHB and <em...